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    <pre style="white-space:pre-line"><code>?대찓?쒖쓽 ?쏄컻?섎Т怨쇰퀝異붿텧遺꾨쭚 ?곌뎄寃곌낵

                               ?앹빟泥?嫄닿컯湲곕뒫?앺뭹 媛쒕퀎?몄젙

                                         2014??媛쒕퀎?몄젙 ?띾뱷
                                         2015??媛쒕퀎?몄젙???먮즺 ?앹궛?ㅼ쟻 4??
                                         ?쒖븣肄붿삱???먯긽?쇰줈遺??媛꾩쓣 蹂댄샇?섎뒗???꾩???以????덉쓬??
                                                     媛쒕퀎?몄젙踰덊샇 2014-01

                                                                                                                   鸚㏝윋?ц뜆耶멩쐝沃???8沅?????2013??11??                                                                ISSN 1229-1765        ?몄껜?곸슜?쒗뿕 ?깃났
                                                                                                                   Kor. J. Herbology 2013竊?8(6)竊?1-38                      http://dx.doi.org/10.6116/kjh.2013.28.6.31.
                                                                                                                                                                                                                                    ?몃챸??숆탳 ?쒖쿇?쒕갑蹂묒썝 ?섑뻾
                                                                                                                         NMED-01怨?NMED-02??媛꾧린??媛쒖꽑??????몄껜 ?⑤뒫 ?됯?                                                                      ?뚯퐫?щ줈 ?명븯??款-GTP媛 ?곸듅????곸옄
                                                                                                                                                                                                                                    12二???랬 ???議곌뎔 ?鍮??좎쓽??媛쒖꽑
                                                                                                                     諛뺤긽??#, 沅뚯슜踰?, 源湲고깭2, ?좎꽑誘?, ?꾧컯??, 怨좏씎2, ?〓?寃?, ?뺤쑄泥?, 源?몄쿋4, 諛뺤＜??*                                                    2017???꾩옱 ?숈닠?쇰Ц??寃뚯젣???좎씪???먮즺

                                                                                                                                            1 : ?대찓???쒖쓽怨쇳븰湲곗닠?곌뎄?? 2 : ?몃챸??숆탳 ?쒖쓽怨쇰????닿낵?숆탳??                                               ?쒖씤泥댁쟻?⑹떆?섏뿉???좎쓽?④낵 ?뺤씤??                                                                                                                                         3 :?몃챸??숆탳 ?쒖쓽怨쇰???蹂몄큹?숆탳?? 4 :寃쏀씗??숆탳 ?쒖쓽怨쇰???蹂몄큹?숆탳??                                                                                                                                                                                                                                    ?몄껜?곸슜?쒗뿕蹂닿퀬?? 2013
                                                                                                                   A Randomized, Double-blind, Placebo-controlled Study to the efficacy and Safety of                               Kor. J. Herbology, 2013
                                                                                                                                     NMED-01 and NMED-02 in Mild Alcoholic Liver Subjects.

                                                                                                                       Sangwoug Park1#, Yongbeom Kwon1, Ki Tae Kim2, Seon Mi Shin2, Kang-hyun Leem3
                                                                                                                             Heung Ko2, MiKyung Song4, Yoon Chul Jung4, Hocheol Kim4, Juyeon Park1*

                                                                                                                                    1 : Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.
                                                                                                                                        2 : Dept. of Internal Medicine, College of Oriental Medicine, Semyung University
                                                                                                                                              3 : Dept. of Herbology, College of Oriental Medicine, Semyung University

                                                                                                                                    4 : Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University

                                                                                                                                                                       ABSTRACT

                                                                                                                   Objectives : The purpose of this study was to determine whether NMED-01 or NMED-02 improves laboratory
                                                                                                                   test results in participants with liver function disorder.
                                                                                                                   Methods : This is a randomized, placebo-controlled trial in which participants, treating physicians and data
                                                                                                                   management staff were blinded to treatment group. The study was conducted at Semyung university oriental
                                                                                                                   medicine hospital in Jecheon where participants with high level of serum 款-GTP (60-350 U/L) were enrolled.
                                                                                                                   The intervention consisted of three times daily ingestion of either two capsules of placebo, NMED-01 (NeuMed.
                                                                                                                   co. ltd., Seoul), or NMED-02 (NeuMed. co. ltd., Seoul) for twelve weeks. To evaluate the efficacy and safety of
                                                                                                                   NMED-01 and NMED-02, we primarily evaluated the degree of decrement of serum 款-GPT level among three
                                                                                                                   groups. Secondarily the decrement of serum ALT, AST, and triglyceride level in each group were also
                                                                                                                   evaluated. Adverse effects were monitored during the twelve weeks treatment.
                                                                                                                   Results : The change of 款-GTP level of NMED-01 group was lower than that of placebo group at the end of
                                                                                                                   12-week administration (28.1짹38.7 U/L vs. 9.3짹27.0 U/L, p=0.046). Other variables including AST, ALT, and
                                                                                                                   triglyceride level were not significantly reduced. The decrement of 款-GPT, AST, ALT, and triglyceride level of
                                                                                                                   NMED-02 group was not significant. There were no significant adverse effects or toxicities during treatment
                                                                                                                   period.
                                                                                                                   Conclusions : Participants receiving NMED-01 had improvement in laboratory test results. Despite a modest
                                                                                                                   sample size, our results suggest that NMED-01 are safe and may be potentially effective in improving liver
                                                                                                                   function. However, NMED-02 have lack of a detectable effect in this study.

                                                                                                                   Key words : Hovenia dulcis, Pueraria lobata, 款-GPT, hepatoprotective effect, alcohol, liver, liver function

                                                                                                                   ??濡?)                                  ?좎? ?쇱긽?앺솢?먯꽌 湲고샇?뚮즺濡쒖꽌 湲댁옣媛??댁냼???됰났媛?異?                                                                                                                                                       援ъ뿉 ?꾩???二쇱?留?怨쇰웾 ??랬?섍굅???κ린媛???랬?섎㈃ ?뚯퐫??
                                                                                                                   *援먯떊???: 諛뺤＜?? ?쒖슱?밸퀎???숇?臾멸뎄 ?대Ц濡?88 3痢?130-831
                                                                                                                    쨌Tel : 02-564-9140 쨌E-mail : saeim@naver.com
                                                                                                                   #?????: 諛뺤긽?? ?쒖슱?밸퀎???숇?臾멸뎄 ?대Ц濡?88 3痢?130-831
                                                                                                                    쨌Tel : 02-564-9140 쨌E-mail : neumed.spark@gmail.com
                                                                                                                    쨌?묒닔竊?013??10??23??쨌?섏젙竊?013??11??05??쨌梨꾪깮竊?013??11??05??
鸚㏝윋?ц뜆耶멩쐝沃???8沅?????2013??7??                                                              ISSN 1229-1765             ?숇Ъ?ㅽ뿕 ?쇰Ц
Kor. J. Herbology 2013竊?8(4)竊?5-32                   http://dx.doi.org/10.6116/kjh.2013.28.4.25.
                                                                                                                   ?뚯＜?듦????곕Ⅸ 湲됱꽦, 留뚯꽦 ?뚯퐫?ъ꽦 ?먯긽 紐⑤몢 媛쒖꽑 ?뺤씤
      ?뚯퐫??諛??ъ뿼?뷀깂?뚯뿉 ?섑빐 ?좊컻??湲됰쭔??媛꾩넀?곸뿉 ???吏援ъ옄                                                                          ?뚯퐫???댁쇅 ?낆꽦 臾쇱쭏濡??명븳 媛??먯긽 媛쒖꽑 ?뺤씤
                                   ?댁닔異붿텧臾쇱쓽 蹂댄샇?④낵
                                                                                                                   ?쒓컙 ?낆꽦, 湲됱꽦, 留뚯꽦 ?뚯퐫?ъ뿉 ?섑빐 ?먯긽??媛?蹂댄샇 ?④낵??                    源?곸떇1#, 諛뺤＜??, 沅뚯슜踰?, ?꾨룞??, ?〓?寃?, 理쒗샇??, 源?몄쿋2*
                                                                                                                   Kor. J. Herbology, 2013
                            1 : ?대찓???쒖쓽怨쇳븰湲곗닠?곌뎄?? 2 : 寃쏀씗??숆탳 ?쒖쓽怨쇰???蹂몄큹?숆탳??
Hepatoprotective Effects of Hovenia dulcis Extract on Acute and Chronic Liver Injuries
                             induced by Alcohol and Carbon Tetrachloride.

     Young-Sik Kim1#, Juyeon Park1, Yongbeom Kwon1, Dong Wook Lim2, MiKyung Song2,
                                            Ho-Young Choi2, Hocheol Kim2*

                    1 : Korea Institute of Science and Technology for Eastern Medicine, NeuMed Co., Ltd.
                   2 : Dept. of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University

                                                    ABSTRACT

Objectives : The purpose of this study was to evaluate the hepatoprotective effect of Hovenia dulcis extract on
acute and chronic liver injuries induced by alcohol and CCl4 in mice and rats.
Methods : In acute alcohol-induced liver injury, mice were administered Hovenia dulcis extracts (60 and 200
mg/kg) orally before and after alcohol administration. In chronic alcohol-induced liver injury, mice were
administered alcohol containing liquid diet for 4 weeks. The mice were administered H. dulcis extracts (60 and
200 mg/kg) mixed with the liquid diet. In acute CCl4-induced liver injury, rats received a single dose of CCl4 (2
mL/kg in olive oil, intraperitoneally). Rats were administered H. dulcis extracts (30, 100 and 300 mg/kg) before
and after CCl4 administrations. After the ends of the administrations, the serum levels of AST and ALT were
measured using chemical analyzer, and 款-GTP levels were measured using spectrophotometer.
Results : In acute alcohol-induced liver injury, H. dulcis extracts treated group showed significant reduction in
ALT levels compared to those of control group. In chronic alcohol-induced liver injury, it inhibited weight-loss
compared to normal group and showed significant reduction in AST, ALT and 款-GTP levels compared to
control group. In acute CCl4-induced liver injury, it also showed significant reduction in AST, ALT levels
compared to control group.
Conclusions : The results show that H. dulcis extract has hepatoprotective effect in acute and chronic
alcohol-induced liver injury and acute CCl4-induced liver injury. These findings suggest that H. dulcis could be
a potent hepatoprotective agent.

Key words : Hovenia dulcis, hepatoprotective effect, carbon tetrachloride, alcohol, liver

                    ??濡?)             留앸쪧 2?꾨? 李⑥??섎뒗 吏덊솚1)?쇰줈 ?앹궛?쒕룞???뺤꽦??40~50?

   媛꾩쭏?섏? ?멸뎄 10留?紐낅떦 13.5紐낆쑝濡??щ쭩?먯씤?쒖쐞 8?꾨?  ???⑸퀝利앹씠 ?쎄쾶 諛쒖깮?섍린 ?뚮Ц??媛?뺤쓽 議대┰???곹뼢??誘?李⑥??섍퀬 ?덉쑝硫? 40??먯꽌???먯궡???쒖쇅?섍퀬 ?붿뿉 ?댁뼱 ??                                      移섍쾶 ?섎ŉ 沅곴레?곸쑝濡??ы쉶???앹궛?깆쓣 ??섏떆?ㅻ뒗 ?붿씤????                                      怨??덈떎2-3). ?곕━?섎씪 留뚯꽦 媛꾩쭏???섏옄瑜???곸쑝濡???議곗궗

*援먯떊???: 源?몄쿋, ?쒖슱?밸퀎???숇?臾멸뎄 寃쏀씗?濡?26 130-701
 쨌Tel : 02-961-0419 쨌E-mail : hckim@khu.ac.kr
#?????: 源?곸떇, ?쒖슱?밸퀎???숇?臾멸뎄 ?대Ц濡?88 3痢?130-831
 쨌Tel : 02-564-9140 쨌E-mail : yjbsik@gmail.com
 쨌?묒닔竊?013??6??19??쨌?섏젙竊?013??7??10??쨌梨꾪깮竊?013??7??19??/code></pre>
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