Abstract
Dracunculus medinensis or Guinea worm was largely considered an exclusive human parasite. The adult female D. medinensis (up to 100 cm long and 1.5–2.0 mm thick) inhabits and moves in the connective tissue, including the skin. Large females protrude from the skin causing unusual and unambiguous signs. Hosts become infected by drinking water containing the crustacean intermediate hosts (cyclopoid copepods known as water fleas) infected with Guinea worm L3 larvae. After years of a successful eradication campaign (focused mainly on preventing humans from drinking unfiltered or untreated water), Guinea worm transmission has been eliminated from most, but not all, countries. An unforeseeable high rate of dog dracunculiasis, mainly in Chad, has been detected as a result of the surveillance program started in 2012. This reverse zoonosis is preventing dracunculiasis from becoming the first infectious disease to be eradicated without a vaccine or specific medical treatment and the second human pathogen eradicated after smallpox. The alternative food-borne route of transmission, in which frogs and fish are involved, suggested by scientists of the Guinea Worm Eradication Program in an attempt to explain dracunculiasis transmission route in dogs, is also discussed.
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References
Adamson PB (1988) Dracontiasis in antiquity. Med Hist 32:204–209
Anderson RC (2000) Nematode parasites of vertebrates. Their development and transmission, 2nd edn. CABI, Wallingford
Bimi L, Freeman AR, Eberhard ML et al (2005) Differentiating Dracunculus medinensis from D. insignis, by the sequence analysis of the 18S rRNA gene. Ann Trop Med Parasitol 99:511–517. https://doi.org/10.1179/136485905X51355
Biswas G, Sankara DP, Agua-Agum J et al (2013) Dracunculiasis (Guinea worm disease): eradication without a drug or a vaccine. Philos Trans R Soc B 368:20120146. https://doi.org/10.1098/rstb.2012.0146
Cairncross S, Muller R, Zagaria N (2002) Dracunculiasis (guinea worm disease) and the eradication initiative. Clin Microbiol Rev 15:223–246. https://doi.org/10.1128/CMR.15.2.223-246.2002
Callaway E (2016) Dogs thwart end to Guinea worm. Nature 529:10–11. https://doi.org/10.1038/529010a
CDC (2016) Guinea worm wrap-up #238. Public Health Service Centers for Disease Control and Prevention
CDC (2017) Guinea worm wrap-up #245. Public Health Service Centers for Disease Control and Prevention
CDC (2018a) Guinea worm wrap-up #258. Public Health Service Centers for Disease Control and Prevention
CDC (2018b) Guinea worm wrap-up #252. Public Health Service Centers for Disease Control and Prevention
CDC (2019a) Guinea worm wrap-up #259. Public Health Service Centers for Disease Control and Prevention
CDC (2019b) Guinea worm wrap-up #262. Public Health Service Centers for Disease Control and Prevention
CDC (2020) Guinea worm wrap-up #265. Public Health Service Centers for Disease Control and Prevention
Cleveland CA, Eberhard ML, Thompson AT et al (2017) Possible role of fish as transport hosts for Dracunculus spp. larvae. Emerg Infect Dis 23:1590–1592. https://doi.org/10.3201/eid2309.161931
Cleveland CA, Garrett KB, Cozad RA et al (2018) The wild world of Guinea worms: a review of the genus Dracunculus in wildlife. Int J Parasitol Parasit Wildl 7:289–300. https://doi.org/10.1016/j.ijppaw.2018.07.002
Cleveland CA, Eberhard ML, Thompson AT et al (2019) A search for tiny dragons (Dracunculus medinensis third-stage larvae) in aquatic animals in Chad, Africa. Sci Rep 9:375. https://doi.org/10.1038/s41598-018-37567-7
Cox FEG (2002) History of human parasitology. Clin Microbiol Rev 15:595–612. https://doi.org/10.1128/cmr.15.4.595-612.2002
Dumiak M (2018) New challenges to eradicating Guinea worm disease. Lancet Infect Dis 18:838. https://doi.org/10.1016/S1473-3099(18)30437-7
Eberhard ML, Ruiz-Tiben E, Hopkins DR et al (2014) The peculiar epidemiology of dracunculiasis in Chad. Am J Trop Med Hyg 90:61–70. https://doi.org/10.4269/ajtmh.13-0554
Edungbola LE (2019) The eradication of dracunculiasis (Guinea worm disease) in Nigeria. Academic, London
Enserink M (2014) Guinea worm eradication at risk in South Sudanese War. Science 343:236. https://doi.org/10.1126/science.343.6168.236
Fedchenko AP (1870a) Concerning the structure and reproduction of the Guinea worm (Filaria medinensis L.). Izvestiia Imperatorskago Obshchestva Liubitelei Estestvoznaniia Antropologii I Ethnografii, Moskova 8:71–81. (In Russian)
Fedchenko AP (1870b) Concerning the structure and reproduction of the Guinea worm (Filaria medinensis L.). Reprinted (1971) in: Am J Trop Med Hyg 20:511–523. https://doi.org/10.4269/ajtmh.1971.20.511
Franz K, Kurtz J (2002) Altered host behaviour: manipulation or energy depletion in tapeworm-infected copepods? Parasitology 125:187–196. https://doi.org/10.1017/s0031182002001932
Gaeta R, Bruschi F, Guiffra V (2017) The painting of St. Roch in the picture gallery of Bari (15th century): an ancient representation of dracunculiasis? J Infect 74:519–521. https://doi.org/10.1016/j.jinf.2017.02.002
Galán-Puchades MT (2016) Dogs and Guinea worm eradication. Lancet Infect Dis 16:770. https://doi.org/10.1016/S1473-3099(16)30080-9
Galán-Puchades MT (2017) WHO delays Guinea-worm disease eradication to 2020: are dogs the sole culprits? Lancet Infect Dis 17:1124–1125. https://doi.org/10.1016/S1473-3099(17)30565-0
Galán-Puchades MT (2018) The Guinea worm: a zoonotic parasite of dogs. Trends Parasitol 34:3–4. https://doi.org/10.1016/j.pt.2017.10.003
Galán-Puchades MT (2019) Dracunculiasis: water-borne anthroponosis vs. food-borne zoonosis. J Helminthol 94:e76. https://doi.org/10.1017/S0022149X19000713
Garret KB, Box EK, Cleveland CA et al (2020) Dogs and the classic route of Guinea worm transmission: an evaluation of copepod ingestion. Sci Rep 10:1430. https://doi.org/10.1038/s41598-020-58191-4
Gooneratne BW (1969) An additional historical note on the transmission of Dracunculus medinensis. Trans R Soc Trop Med Hyg 63:546
Joshi V (1992) Dracunculiasis in Jodhpur district: studies on some epidemiological and parasitological aspects. JoCD 24:191–193
Joshi V, Singhi M, Chaudhary RC (1997) Studies on dracunculiasis in the Indian Desert. J Arid Environ 37:181–191
LID (2019) Dracunculiasis—a case study for infection eradication. Lancet Infect Dis 19:1149. https://doi.org/10.1016/S1473-3099(19)30488-8
Litvinov SK (1991) How the USSR rid itself of dracunculiasis. World Health Forum 12:217–219
Messenger AM, Barnes AN, Gray GC (2014) Reverse zoonotic disease transmission (zooanthroponosis): a systematic review of seldom-documented human biological threats to animals. PLoS One 9:e89055. https://doi.org/10.1371/journal.pone.0089055
Miller RL (1989) Dqr, spinning and treatment of Guinea worm in P. Ebers 875. J Egypt Archaeol 75:249–254. http://www.jstor.org/stable/3821922
Molyneux D, Sankara DP (2017) Guinea worm eradication: progress and challenges-should we beware of the dog? PLoS Negl Trop Dis 11:e0005495. https://doi.org/10.1371/journal.pntd.0005495
Moorthy VN (1932) An epidemiological and experimental study of dracontiasis in Chitaldrug district. Indian Med Gaz 67:498–504
Muller R (1971) Dracunculus and dracunculiasis. Adv Parasitol 9:73–151. https://doi.org/10.1016/s0065-308x(08)60160-8
Muller R (2002) Worms and human disease. CABI, Wallingford. https://doi.org/10.1079/9780851995168.0000
National Research Council (1983) Opportunities for control of dracunculiasis. Report of a workshop. National Academic Press, Washington, DC. https://doi.org/10.17226/19479
Nunn JF, Tapp E (2000) Tropical diseases in ancient Egypt. Trans R Soc Trop Med Hyg 94:147–153. https://doi.org/10.1016/S0035-9203(00)90252-9
Onabamiro SD (1951) The transmission of Dracunculus medinensis by Therocyclops nigarianusas observed in a village in south-west Nigeria. West Afr Med J 1:159–160
Onabamiro SD (1954) The diurnal migration of cyclops infected with the larvae of Dracrunculus medinensis (Linnaeus), with some observations on the development of the larval worms. West Afr Med J 3:189–194
Pasternak AF, Huntingford FA, Crompton DW (1995) Changes in metabolism and behaviour of the freshwater copepod Cyclops strenuus abyssorum infected with Diphyllobothrium spp. Parasitology 110:395–399. https://doi.org/10.1017/s0031182000064738
Pichakacheri SK (2019) Guinea worm (Dracunculus medinensis) infection presenting as a diabetic foot abscess: a case report from Kerala. Natl Med J India 32:22–23. https://doi.org/10.4103/0970-258X.272111
Pulkkinen K, Pasternak AF, Hasu T et al (2000) Effect of Triaenophorus crassus (Cestoda) infection on behavior and susceptibility to predation of the first intermediate host Cyclops strenuus (Copepoda). J Parasitol 86:664–670. https://doi.org/10.1645/0022-3395(2000)086[0664:EOTCCI]2.0.CO;2
Roberts L (2019) Battle to wipe out Guinea worm stumbles. Nature 574:157–158. https://doi.org/10.1038/d41586-019-02921-w
Ruiz-Tiben E, Hopkins DH (2006) Dracunculiasis (Guinea worm disease) eradication. Adv Parasitol 61:275–309. https://doi.org/10.1016/S0065-308X(05)61007-X
Shetty A, Shetty S, Dsouza O (2014) Medical symbols in practice: myths vs reality. J Clin Diagn Res 8:12–14. https://doi.org/10.7860/JCDR/2014/10029.4730
Smith GS, Blum D, Huttly SRA et al (1989) Disability from dracunculiasis: effect on mobility. Ann Trop Med Parasitol 83:151–158. https://doi.org/10.1080/00034983.1989.11812323
Sreenivasan N, Weiss A, Djiatsa J-P et al (2017) Recurrence of Guinea worm disease in Chad after a 10-year absence: risk factors for human cases identified in 2010-2011. Am J Trop Med Hyg 97:575–582. https://doi.org/10.4269/ajtmh.16-1026
Teshome H (2019) Review on principles of zoonoses prevention, control and eradication. Am J Biomed Sci Res 3:188–197. https://doi.org/10.34297/AJBSR.2019.03.000660
Thiele EA, Eberhard ML, Cotton JA et al (2018) Population genetic analysis of Chadian Guinea worms reveals that human and non-human hosts share common parasite populations. PLoS Negl Trop Dis 12:e0006747. https://doi.org/10.1371/journal.pntd.0006747
Velschius GH (1674) Exercitationes de vena medinensis et de vermiculis capillaribus infantium. Auguste Vindel, Augsburg
Whitty CJ (2015) Political, social and technical risks in the last stages of disease eradication campaigns. Int Health 7:302–303. https://doi.org/10.1093/inthealth/ihv049
WHO (1996) Criteria for the certification of dracunculiasis eradication. WHO/FIL/96. 187 Rev. 1
WHO (2007) Global plan to combat neglected tropical diseases 2008–2015. World Health Organization, Geneva. WHO/CDS/NTD/2007.3
Williams BM, Cleveland CA, Verocai GG et al (2018) Dracunculus infections in domestic dogs and cats in North America; an under-recognized parasite? Vet Parasitol: Reg Stud Rep 13:148–155. https://doi.org/10.1016/j.vprsr.2018.05.005
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Galán-Puchades, M.T. (2021). Guinea Worm Infection in Dogs: A Case of Reverse Zoonosis that Impedes Dracunculus medinensis Eradication. In: Strube, C., Mehlhorn, H. (eds) Dog Parasites Endangering Human Health. Parasitology Research Monographs, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-53230-7_12
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