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승마
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일반정보
| 일반명 | Cimicifuga rhizome, Large trifoliolious bugbane rhizome |
|---|---|
| 라틴명 | Cimicifuga rhizome |
| 이명 | 주승마(周升麻)․주마(周麻)․계골승마(鷄骨升麻)․관승마(關升麻)․녹승마(綠升麻) |
| 학명 | Cimicifuga heracleifolia Komarov (승마), Cimicifuga simplex Wormskjord (촛대승마), Cimicifuga dahurica Maximowicz (눈빛승마). Cimicifuga foetida Linné (황새승마) |
| 기원 | 승마 Cimicifuga heracleifolia Komarov, 촛대승마 Cimicifuga simplex Wormskjord, 눈빛승마 Cimicifuga dahurica Maximowicz 또는 황새승마 Cimicifuga foetida Linné의 뿌리줄기 |
| 약성/귀경 | 맵고(辛) 약간 달고(微甘) 약간 차다(微寒). 폐(肺), 비(脾), 위(胃), 대장경(大腸經)에 작용한다. |
| 효능 | 발표투진(發表透疹), 청열해독(淸熱解毒), 승양거함(昇陽擧陷) 발표(發表): any formula that is composed of exterior-releasing medicinals, has diaphoretic, muscle-releasing and eruption-promoting effects, and is used to treat exterior patterns/syndromes 투진(透疹): a therapeutic method used to promote skin eruption in measles for preventing complications, the same as promoting eruption 청열해독(淸熱解毒): a medicinal that counteracts heat toxins |
성분정보
*계열/성분을 클릭하면 구조 및 상세정보를 볼 수 있습니다.
일반정보
| 일반명 | Cimicifuga rhizome, Large trifoliolious bugbane rhizome |
|---|---|
| 라틴명 | Cimicifuga rhizome |
| 이명 | 주승마(周升麻)․주마(周麻)․계골승마(鷄骨升麻)․관승마(關升麻)․녹승마(綠升麻) |
| 학명 | Cimicifuga heracleifolia Komarov (승마), Cimicifuga simplex Wormskjord (촛대승마), Cimicifuga dahurica Maximowicz (눈빛승마). Cimicifuga foetida Linné (황새승마) |
| 기원 | 승마 Cimicifuga heracleifolia Komarov, 촛대승마 Cimicifuga simplex Wormskjord, 눈빛승마 Cimicifuga dahurica Maximowicz 또는 황새승마 Cimicifuga foetida Linné의 뿌리줄기 |
| 약성/귀경 | 맵고(辛) 약간 달고(微甘) 약간 차다(微寒). 폐(肺), 비(脾), 위(胃), 대장경(大腸經)에 작용한다. |
| 효능 | 발표투진(發表透疹), 청열해독(淸熱解毒), 승양거함(昇陽擧陷) 발표(發表): any formula that is composed of exterior-releasing medicinals, has diaphoretic, muscle-releasing and eruption-promoting effects, and is used to treat exterior patterns/syndromes 투진(透疹): a therapeutic method used to promote skin eruption in measles for preventing complications, the same as promoting eruption 청열해독(淸熱解毒): a medicinal that counteracts heat toxins |
| 관련링크명 | 구분 | URL | 바로가기 |
|---|---|---|---|
| 한국전통지식포탈 | 승마A | www.koreantk.com/ktkp2014/medicine/medicine-view.view?medCd=M0002246 | 바로가기+ |
| 한국전통지식포탈 | 승마B | www.koreantk.com/ktkp2014/medicine/medicine-view.view?medCd=M0002247 | 바로가기+ |
| 한국전통지식포탈 | 승마C | www.koreantk.com/ktkp2014/medicine/medicine-view.view?medCd=M0002248 | 바로가기+ |
| 한국전통지식포탈 | 승마D | www.koreantk.com/ktkp2014/medicine/medicine-view.view?medCd=M0002249 | 바로가기+ |
| 식약처 생약종합정보시스템 | 촛대승마 | www.nifds.go.kr/nhmi/hbdc/ofcmhbdc/view.do?selectedDmstcOfcmNo=301&selectedMdntfNo=569 | 바로가기+ |
| 식약처 생약종합정보시스템 | 승마 | www.nifds.go.kr/nhmi/hbdc/ofcmhbdc/view.do?selectedDmstcOfcmNo=301&selectedMdntfNo=568 | 바로가기+ |
| 식약처 생약종합정보시스템 | 눈빛승마 | www.nifds.go.kr/nhmi/hbdc/ofcmhbdc/view.do?selectedDmstcOfcmNo=301&selectedMdntfNo=570 | 바로가기+ |
| 식약처 생약종합정보시스템 | 황새승마 | www.nifds.go.kr/nhmi/hbdc/ofcmhbdc/view.do?selectedDmstcOfcmNo=301&selectedMdntfNo=571 | 바로가기+ |
주요성분 (5)
| 계열 | 성분 | 구조 | 링크 | 효능 |
|---|---|---|---|---|
| triterpenoid | cimigenol |
|
|
간보호작용, 항암 |
| triterpenoid | cimicifugoside |
|
|
항암작용 |
| chromone | cimifugin |
|
|
항염 |
| xanthone | visnagin |
|
|
항암, 항균 |
| phenylpropanoid | fukinolic acid |
|
|
여성호르몬 유사작용 |
신규성분 (20)
| 계열 | 성분 | 구조 | 서지사항 |
|---|---|---|---|
| saponin | 3β,16α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24R,25-epoxy-cycloartane-3-O-β-D-galactopyranoside (1), 3β,16α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24R,25-epoxy-cycloartane-7-ene-3-O-β-D-xylopyranoside (2) |
|
Su Y, Wu L, Wang Q, Yang B, Kuang H. New 9,19-cycloartenol glycosides isolated from the roots of Cimicifuga simplex and their anti-inflammatory effects. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5688-91. PubMed |
| saponin | two new cycloartane triterpenoids (1, 2), eight new cycloartane glycosides (3-10) |
|
Chen JY, Li PL, Tang XL, Wang SJ, Jiang YT, Shen L, Xu BM, Shao YL, Li GQ. Cycloartane triterpenoids and their glycosides from the rhizomes of Cimicifuga foetida. J Nat Prod. 2014 Sep 26;77(9):1997-2005. PubMed |
| triterpenoid | 9,19-cycloartane triterpenes, (3β, 12β, 15α, 24R)-12, 2′-diacetoxy-24, 25-epoxy-15-hydroxy-16, 23-dione-3-O-α-L-arabinopyranoside |
|
Zhu DF, Nian Y, Wang HY, Zhang ZR, Song YB, Li RT, Qiu MH. New 9, 19-cycloartane triterpenoid from the root of Cimicifuga foetida. Chin J Nat Med. 2014 Apr;12(4):294-6. PubMed |
| triterpenoid | 9,19-cycloartane triterpenes (1-12) |
|
Nian Y, Wang HY, Zhou L, Su J, Li Y, Qiu MH. Cytotoxic cycloartane triterpenes of the traditional Chinese medicine "shengma" (Cimicifuga dahurica). Planta Med. 2013 Jan;79(1):60-9. PubMed |
| saponin | heracleifolinosides A-F |
|
Liu YR, Wu ZJ, Li CT, Xi FM, Sun LN, Chen WS. Heracleifolinosides A-F, new triterpene glycosides from Cimicifuga heracleifolia, and their inhibitory activities against hypoxia and reoxygenation. PubMed |
| saponin | 23-O-acetylshengmanol 3-O-α-L-arabinopyranoside (1), 23-O-acetylshengmanol 3-O-β-D-xylopyranoside (2), 24-epi-24-O-acetylhydroshengmanol 3-O-β-D-xylopyranoside (3), cimiaceroside B (4), (23R,24S)-cimigenol 3-O-β-D-xylopyranoside (5), (23R,24R)-25-O-acetylcimigenol 3-O-β-D-xylopyranoside (6), (23R,24S)-25-O-anhydrocimigenol 3-O-β-D-xylopyranoside (7) |
|
Lee JH, Cuong TD, Kwack SJ, Seok JH, Lee JK, Jeong JY, Woo MH, Choi JS, Lee HK, Min BS. Cycloartane-type triterpene glycosides from the rhizomes of Cimicifuga heracleifolia and their anticomplementary activity. Planta Med. 2012 Aug;78(12):1391-4. PubMed |
| saponin | 3 β,16 α-dihydroxy-12-acetoxy-16,22-cyclo-23-ketone-24 R,25-epoxy-cycloartane-7-ene 3-O-β-D-galactopyranoside (1), 24-O-hydroxy-7,8-didehydrohydroshengmanol 3-O-β-D-galactopyranoside (2), 24-epi-24-O-hydroxy-7,8-didehydrohydroshengmanol 3-O-β-D-galactopyranoside (3) |
|
Kuang H, Su Y, Wang Q, Wu L, Yang B, Wang Z, Xia Y. Three new cycloartenol glycosides from the roots of Cimicifuga simplex. Planta Med. 2012 Apr;78(6):622-5. PubMed |
| saponin | 24-epi-cimigenol-3-one (1), foetinoside (2) |
|
Lu L, Chen JC, Li Y, Qing C, Wang YY, Nian Y, Qiu MH. Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities. Chem Pharm Bull (Tokyo). 2012;60(5):571-7. PubMed |
| chromone | cimifugin-4'-O-[6''-feruloyl]-β-D-glucopyranoside (3) |
|
Lu L, Chen JC, Li Y, Qing C, Wang YY, Nian Y, Qiu MH. Studies on the constituents of Cimicifuga foetida collected in Guizhou Province and their cytotoxic activities. Chem Pharm Bull (Tokyo). 2012;60(5):571-7. PubMed |
| sterol | cimisterol A (1) |
|
Nian Y, Wang HY, Su J, Zhou L, Qiu MH. A cytotoxic 4α-methyl steroid from the aerial parts of Cimicifuga foetida L. Fitoterapia. 2012 Mar;83(2):293-7. PubMed |
| saponin | 15-hydroxy-trinor type (1-3), tetranor type (4), 3,15,23,24-tetrahydroxy-16-oxo type cycloartane glycosides (5, 6) |
|
Nishida M, Yoshimitsu H. Six new cycloartane glycosides from cimicifuga rhizome. Chem Pharm Bull (Tokyo). 2011;59(10):1243-9. PubMed |
| saponin | shengmaxinsides A-C |
|
Kuang H, Su Y, Yang B, Xia Y, Wang Q, Wang Z, Yu Z. Three New Cycloartenol Triterpenoid Saponins from the Roots of Cimicifuga simplex Wormsk. Molecules. 2011 May 25;16(6):4348-57. PubMed |
| saponin | 9,19-cycloartane triterpene glycosides (1-2) |
|
Sun LR, Yan J, Zhou L, Li ZR, Qiu MH. Two new triterpene glycosides with monomethyl malonate groups from the rhizome of Cimifuga foetida L. Molecules. 2011 Jul 5;16(7):5701-8. PubMed |
| etc | fukiic acid derivatives (1-7), phenylethanoid derivative (8) |
|
Iwanaga A, Kusano G, Warashina T, Miyase T. Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia). J Nat Prod. 2010 Apr 23;73(4):573-8. PubMed |
| etc | fukinolic acid analogues, cimicifugic acids K-N (1-4), phenolic glycoside, shomaside F (5) |
|
Iwanaga A, Kusano G, Warashina T, Miyase T. Phenolic constituents of the aerial parts of Cimicifuga simplex and Cimicifuga japonica. J Nat Prod. 2010 Apr 23;73(4):609-12. PubMed |
| saponin | foetidinosides A (1), B (2), C (3), D (4), E (5) |
|
Lu L, Chen JC, Song HJ, Li Y, Nian Y, Qiu MH. Five new triterpene bisglycosides with acyclic side chains from the rhizomes of Cimicifuga foetida L. Chem Pharm Bull (Tokyo). 2010 May;58(5):729-33. PubMed |
| saponin | 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), 3'-O-acetyl-23-epi-26-deoxyactein (7) |
|
Nian Y, Zhang YL, Chen JC, Lu L, Qiu MH, Qing C. Cytotoxic chemical constituents from the roots of Cimicifuga foetida. J Nat Prod. 2010 Feb 26;73(2):93-8. PubMed |
| saponin | 15alpha-hydroxy-16-dehydroxy-16(24)-en-foetidinol-3-O-beta-D-xylopyranoside (1), 28-hydroxy-foetidinol-3-O-beta-D-xylopyranoside (2), foetidinol-3-O-beta-D-xylopyranosyl-(1''→3')-beta-D-xylopyranoside (3) |
|
Lu L, Chen J, Nian Y, Sun Y, Qiu M. Trinor-cycloartane glycosides from the rhizomes of Cimicifuga foetida. Molecules. 2009 Apr 17;14(4):1578-84. PubMed |
| saponin | cimiaceroside C (1), cimifosides A-D (2-5) |
|
Sun L, Yan J, Nian Y, Zhou L, Zhang H, Qiu M. New triterpene diglycosides from the rhizome of Cimifuga foetida. Molecules. 2008 Aug 13;13(8):1712-21. PubMed |
| saponin | cimicifugadine (1) |
|
Dan C, Zhou Y, Ye D, Peng S, Ding L, Gross ML, Qiu SX. Cimicifugadine from Cimicifuga foetida, a new class of triterpene alklaoids with novel reactivity. Org Lett. 2007 Apr 26;9(9):1813-6. PubMed |
약리정보
* 질병 분류 별 논문 수
| 질병 분류 | 임상 시험 human |
동물 실험 in vivo |
세포 및 시험관 실험 in vitro |
total (건) |
|---|---|---|---|---|
| 전염병 또는 기생충병(I) | 0 | 0 | 2 | 2 |
| 종양(II) | 1 | 2 | 21 | 24 |
| 혈액 및 혈액 생성 기관 질병으로 면역 체계와 관련된 병(III) | 0 | 0 | 3 | 3 |
| 내분비선 영양 및 순환계(IV) | 2 | 1 | 1 | 4 |
| 순환 계통의 질병(IX) | 0 | 0 | 2 | 2 |
| 호흡기 계통의 질병(X) | 0 | 0 | 1 | 1 |
| 소화 계통의 질병(XI) | 0 | 0 | 1 | 1 |
| 피부와 피하 조직의 질병(XII) | 0 | 1 | 2 | 3 |
| 근육과 연결 조직의 질병(XIII) | 0 | 2 | 2 | 4 |
| 항산화 또는 항염증(XXIII) | 0 | 1 | 2 | 3 |
| 기타(XXIV) | 0 | 1 | 1 | 2 |
| 합계 | 3 | 8 | 38 | 49 |
*숫자를 클릭하면 약리작용 상세정보를 볼 수 있습니다.